Jia-Peng Chen

Pop-Corn: Predicting Perturbation Phenotype Effects Across Single-Cell and Spatial Contexts

Genetic perturbations can reshape cell populations by altering the relative abundance of specific cell types and states within the profiled population, including increases, decreases and states that become detectable after perturbation. Pooled single-cell screens, such as Perturb-seq, measure such responses at scale. H...