Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcription factor activity by directly binding c...
Ya-Ping Xu, Xin-Yan Han, Jun-Ming Li et al.· Oncogene· 0 citations
A comprehensive and up-to-date overview of AI-driven PTM site prediction across more than ten PTM classes, covering single-PTM site prediction, multiple-PTM site prediction, inter-site crosstalk prediction, and functional prediction of modification sites is provided.
Jia-Yi Ran, Xiao-Han Zhang, Yun-Ze Wang et al.· Genomics, Proteomics & Bioin...· 0 citations
This paper proposes TextDTI, a multimodal framework that simultaneously exploits sequential and structural representations and enhances feature alignment through adversarial learning and contrastive loss, resulting in robust and high-performance DTI prediction.
Jia-Qi Deng, Senyu Tang, Ji-Jun Tang et al.· Journal of Chemical Informat...· 0 citations
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