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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Jia-Qiang Ren

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Review Open access Sep 2026

In Vivo CAR-T Cell Engineering: Translating Vector Pharmacology into Therapeutic Performance

In Vivo CAR-T cell engineering delivers chimeric antigen receptor (CAR) molecules transgenes directly to endogenous T cells using lentiviral vectors or targeted lipid nanoparticles, bypassing the manufacturing processes of ex vivo cellular therapies. Lentiviral vectors provide integration-based expression for sustained...

David F. Stroncek, Jia-Qiang Ren, Anh Dinh · 0 citations

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