Impact of frailty phenotype on chronic disease accumulation and healthy life years lost: A multi-state analysis of the UK Biobank
Background Frailty is a systemic vulnerability syndrome linked to adverse health outcomes, yet its role in shaping the dynamic trajectory from health through incident disease to multimorbidity remains poorly understood. Methods Among 276,696 disease-free UK Biobank participants (mean age 55.3 years; 53.5% female; media...