GSK3β-mediated phosphorylation of IF1 at Ser27 destabilizes mitochondrial ATP synthase inhibitory factor 1 to aggravate cardiac ischemia/reperfusion injury.
OBJECTIVES Myocardial ischemia-reperfusion (I/R) injury is a major cause of ischemic cardiomyopathy and chronic heart failure, underscoring the need for new cardioprotective strategies. ATP synthase inhibitory factor 1 (IF1) maintains mitochondrial function and limits oxidative damage during I/R injury. Our previous wo...