PTP1B in dorsal root ganglion nociceptors drives neuropathic pain via a presynaptic Src/GluN2B signaling pathway.
BACKGROUND Neuropathic pain, a debilitating chronic condition, remains a major clinical challenge due to its complex pathogenesis and limited treatment options. Protein tyrosine phosphatase 1B (PTP1B), a key regulator of tyrosine phosphorylation, has been implicated in various diseases, yet its specific role and mechan...