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Jia-Xin Liu

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Sep 2026

Astragaloside IV attenuates cerebral ischemia-reperfusion injury by suppressing PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress through activation of the SHH signaling pathway.

BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SH...

Ping-Bo Wei, Yang-Yun Han, Jun Wang et al. · 0 citations

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