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Author

Jia-Xin Liu

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Open access Oct 2026

Mitochondrial transfer protects against cisplatin-induced hearing loss by fumarate-mediated activation of mitophagy.

Sensorineural hearing loss (SNHL) affects millions of individuals worldwide, with platinum-based chemotherapeutics identified as a significant cause. In this study, we elucidate the mechanism by which mitochondrial transfer from mesenchymal stem/stromal cells (MSCs) protects against cisplatin-induced cochlear injury in...

Yun-Hao Wu, Yun-Hui Gu, Yu-Kai Wang et al. · 0 citations
Open access Sep 2026

Herbal Formula AC591 Protects Against Cisplatin‐Induced Hearing Loss by Inhibiting p53‐Mediated Ferroptosis

It is shown that AC591, derived from the classical herbal formula “Huangqi Guizhi Wuwu decoction,” exhibits notable protective effects on cisplatin‐induced ototoxicity, and 18β‐glycyrrhetinic acid may serve as promising agents for preventing CIHL.

Yun-Hao Wu, Yu Tao, Lin Wei et al. · 0 citations
Sep 2026

Metformin Use and Risk of Incident Hearing Loss Among Participants With Diabetes: A UK Biobank Cohort Study.

AIMS To investigate the association between baseline metformin use and incident hearing loss among participants with diabetes in the UK Biobank. MATERIALS AND METHODS This study included participants from the UK Biobank who had been diagnosed with diabetes before baseline and had no evidence of hearing loss (N = 24 9...

Xi-Jia Xin, Kun Zhang, Wen-He Yu et al. · 0 citations

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