Open access
Aug 2026
Sustainable Synthesis of Pyrano[3,2‐c]Chromenes With Dual Antioxidant and Anti‐Inflammatory Activities Using a Recyclable 1,3‐Butanediol/ChCl/Ammonia (B‐DES/NH 3 ) System
Pyrano[3,2‐c]chromenes are of significant interest in both biology and synthetic methodology. In a one‐pot three‐component reaction of 4‐hydroxycoumarin, malononitrile (or 1,3‐dicarbonyl compound), and aldehyde, basic conditions were found to promote the synthesis for the first time, with ammonia identified as the...
Qi-Sheng Li, Weicheng Zhang, Lu Yan et al.
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