Review
Open access
Sep 2026
Cardiomyocyte Calcium Homeostasis Remodeling in Diabetes-Related HFpEF: Mechanisms and Therapeutic Perspectives.
More direct approaches, including modulation of Ca2+-handling proteins, ryanodine receptor 2 (RyR2) stabilization, sarcoplasmic reticulum Ca2-ATPase 2a (SERCA2a) restoration, and repair of T-tubule-associated microdomains, remain largely preclinical or early translational.
Ke-Xin Zhang, Jia-Xuan Lan, Yan Leng et al.
· Pharmacological Research · 1 citation