Jia-Xuan Yang

Paired single-nucleus and spatial transcriptomics of the lung adenocarcinoma invasion sequence reveal niche domains and candidate reversal compounds

Lung adenocarcinoma (LUAD) develops through a defined morphological sequence from atypical adenomatous hyperplasia (AAH) to invasive adenocarcinoma, but the transcriptional programmes accompanying this transition have mostly been characterised in bulk tissue or in tumour tissue alone. We profiled paired samples spannin...