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Review Open access Aug 2026

Fatty acid-binding protein 2 in inflammatory bowel disease: mechanistic insights and translational perspectives

Fatty acid-binding protein 2 (FABP2) is an intestine-specific cytoplasmic lipid chaperone with a molecular weight of approximately 14–15 kDa that plays a pivotal role in the uptake, intracellular trafficking, and metabolism of long-chain fatty acids. Emerging evidence indicates that FABP2 is not only a sensitive biomar...

Shu-Hang Zhong, Kai-Shuo Lv, Xiao-Qing Liu et al. · 0 citations
Open access Sep 2026

Single-cell immune repertoire atlas maps coordinated circulating adaptive immune states in inflammatory bowel disease

Single-cell studies have defined immune states in inflammatory bowel disease (IBD), but how adaptive receptor histories organize circulating immunity remains unclear. We generated a single-cell transcriptomic atlas of peripheral blood from 249 participants with Crohn’s disease, ulcerative colitis, or non-IBD control st...

J. Gubatan, Jia-Yu Ye, Christin Lund-Andersen et al. · 0 citations
Open access Aug 2026

Transcriptomic analysis identifies FABP5 as a candidate regulator of lipid accumulation in metabolic dysfunction-associated fatty liver disease

Objective The pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD) is very complex, which has not been fully revealed as so far. This study aimed to identify differentially expressed genes involved in the pathogenesis of MAFLD using Oxford Nanopore Technologies (ONT) transcriptomic sequencing an...

Kai-Shuo Lv, Shu-Hang Zhong, Xiao-Qing Liu et al. · 0 citations

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