hnRNPC facilitates coronavirus replication by directly binding the frameshift-stimulatory element of viral genomic RNA
HnRNPC is identified as a key host cofactor for coronaviruses and provides a novel target for broad-spectrum antiviral drug development and the small molecule Elbasvir directly binds hnRNPC, disrupting the interaction between hnRNPC and FSE RNA and inhibiting coronavirus replication by decreasing –1 PRF efficiency.