Reduced SPARC in trophoblast promotes decidual M1 macrophage polarization and trophoblast dysfunction.
Missed abortion (MA) is a complex pregnancy complication with multifactorial etiologies, including embryonic chromosomal anomalies and maternal endocrine disorders. Among these, immune dysregulation at the maternal-fetal interface has been recognized as a critical contributing factor. Secreted protein acidic and rich i...