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The current H5N1 panzootic has seen an unprecedented host range expansion, including sustained circulation in US dairy cattle, detected in March 2024. By July 2026, infections had been reported on more than 1,150 dairy farms across 19 states. Although the outbreak initially centred in Texas, California has emerged as t...
A new paradigm for the evolutionary drivers of haemagglutinin is presented, where reduced sialic acid binding can serve as an advantage for escape from host barriers and antivirals.
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