Jialin Cheng

TransBind2: Improving Transcription Factor-DNA Binding Prediction with Multimodal Data and Bidirectional Cross Attention

Accurate genome-wide prediction of transcription factor (TF)–DNA binding remains challenging because many models focus mainly on DNA sequence and overlook chromatin context and TF structure. We previously developed TransBind, a protein-aware model that combines TF and DNA representations through cross-attention. Here,...