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Author

Jian-Bin Ruan

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2 papers indexed here

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Open access Aug 2026

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1

The non-canonical caspase-4 inflammasome is a crucial anti-bacterial immune mechanism, yet, when dysregulated, may contribute to sepsis pathogenesis. Its regulation is heavily reliant on transcriptional control of caspase-4 expression. However, posttranslational regulation of the caspase-4 inflammasome remains poorly u...

Duo-Meng Yang, Jason G. Cahoon, T. Geng et al. · 0 citations
Review Sep 2026

Structural Insights into MLKL-Mediated Necroptosis: Emerging Mechanisms.

Necroptosis is a regulated form of lytic cell death that plays important roles in inflammation, host defense, and disease. Central to this pathway is mixed lineage kinase domain-like protein (MLKL), the terminal effector responsible for membrane disruption. Upon phosphorylation by receptor-interacting protein kinase 3...

Brooke Dreyer, Jian-Bin Ruan · 0 citations

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