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Author

Jian-Bo Sun

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Open access Sep 2026

Cinnamaldehyde-loaded gold nanobipyramids for dual-amplification of oxidative stress to enhance cancer catalytic therapy.

Various inorganic nanozymes have been developed to generate highly reactive hydroxyl radicals (˙OH) through enzyme-mimetic catalytic activity for applications in catalytic therapy. However, the elevated levels of the antioxidant glutathione (GSH) in tumor cells can effectively neutralize ˙OH, thereby diminishing the th...

Ting Yin, Yi-Xin Wang, Ming-Yuan Li et al. · 0 citations
Sep 2026

JNK acts as a molecular brake of the CDC73 positive feedback loop to modulate osteosarcoma malignant progression via UBR5.

A novel JNK-dependent UBR5-CDC73 axis is defined that acts as a molecular brake of the CDC73 positive feedback loop to orchestrate transcriptional programs, providing new mechanistic insights into CDC73 post-translational regulation in tumorigenesis and promising therapeutic targets for CDC73-dysregulated diseases.

Ding-Ji Li, Xin-Chen Wang, Hui-Gen Luo et al. · 0 citations

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