Open access
Aug 2026
Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury.
Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lactate as a key metabol...
Li-Jun Dong, Jingwen Xie, Mengyuan Tao et al.
· Journal of Clinical Investig... · 0 citations