Author

Jian-Fei Huang

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Open access Oct 2026

ENOPH1 orchestrates KRASG12D/G13D-driven glycolytic reprogramming and colorectal cancer progression through modulating the TGF-β/SMAD pathway.

Oncogenic KRAS mutations (G12D/G13D) drive metabolic reprogramming in colorectal cancer (CRC), yet targetable downstream effectors remain poorly defined. Here, we identify enolase-phosphatase 1 (ENOPH1) as an essential transducer directly upregulated by the KRAS-MEK-ERK axis. ENOPH1 is markedly elevated in KRAS-mutant...

Xin Chen, Yi-Ren Su, Zhi-Zhan Ni et al. · International Immunopharmaco... · 0 citations

Oct 2026

Targeting the Metabolic-Immune Regulator SLC35F6 Enhances Temozolomide and Anti-PD-L1 Therapy in Glioma.

Single-pathway targeted therapy is often insufficient to control malignant glioma progression, and the blood-brain barrier (BBB) remains a major obstacle to effective drug delivery. Therefore, discovering multifunctional target molecules and corresponding drugs that can penetrate the BBB can provide new strategies for...

Peng-Peng Lu, Wei Wang, Bing Lu et al. · Cancer Letters · 0 citations