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Author

Jian-Guo Tang

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Open access Sep 2026

Early adjunctive vasopressin was not associated with a lower 7-day risk of renal replacement therapy in norepinephrine-treated patients with cirrhosis: a target-trial-informed study with external replication

Background Early adjunctive vasopressin can reduce catecholamine exposure in vasodilatory shock, but whether it prevents severe kidney failure in norepinephrine-treated patients with cirrhosis is uncertain. Methods We conducted a target-trial-informed landmark study using MIMIC-IV as the primary cohort and eICU-CRD as...

Wei Zhang, Ke-Yan Miao, Hui Chen et al. · 0 citations
Open access Aug 2026

Associations of Heart Rate Trajectories with Mortality and AKI Occurrence in Septic Patients: A Retrospective Study from MIMIC-IV and eICU Databases

Background: Abnormal heart rate is a common early manifestation of sepsis, but the association of the dynamic changes with clinical outcomes remains unclear. This study aimed to investigate the relationship between dynamic heart rate trajectories and 28-day mortality as well as acute kidney injury (AKI) in patients wit...

Yang Yang, Hang-Xiang Du, Zhen-Liang Wen et al. · 0 citations

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