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Jian-Heng Zhou

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Open access Sep 2026

Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway.

Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and YTHDF proteins are frequently overexpressed in this malignancy, which correlates with adverse prognosis. Through high-throughput drug screening, we identify ellagic acid (EA) as a compound that binds to YTHDF proteins and disrupts their intera...

Jian-Heng Zhou, Yu-Yuan Li, Xue-Tao Chen et al. · 0 citations

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