Author

Jian-Hua Peng

2 papers indexed here

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Open access Aug 2026

S1P1-mediated metabolic reprogramming promotes astrocytic mitochondrial dysfunction via histone lactylation in subarachnoid hemorrhage

Mitochondrial dysfunction is a central event in the pathophysiology of subarachnoid hemorrhage (SAH). Accumulating evidence has demonstrated that mitochondrial function is vulnerable to metabolic alterations. While the role of neuronal mitochondrial dysfunction in SAH pathology is firmly established, less is know...

Li-Fang Zhang, J. Pang, Chaojie Li et al. · Cell Communication and Signa... · 0 citations

Open access Sep 2026

CDK8 regulates definitive endoderm commitment through cAMP-lysosomal homeostasis and neuroectodermal suppression

Definitive endoderm (DE) specification is essential for gastrointestinal and respiratory organogenesis, yet upstream regulators that integrate signaling pathways with metabolic and epigenetic cues remain poorly understood. Here, we identified cyclin-dependent kinase 8 (CDK8) as an important regulator of human DE co...

Chun-Mei Xian, A. Huang, Zheng Bao et al. · Cell Death & Disease · 0 citations