Author

Jian-Huang Huang

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Sep 2026

Endoplasmic Reticulum Stress Drives Carotid Atherosclerotic Plaque Instability: Integrative Insights into Biomarkers and Therapeutic Targets

Carotid atherosclerosis is a leading cause of stroke, with plaque rupture closely linked to endoplasmic reticulum stress (ERS). However, the precise mechanisms of ERS in plaque instability remain incompletely understood. This study aims to investigate the role of ERS in carotid plaque instability, identify potentia...

Hai-Feng Zhou, Zhi-Wei Zhang, Jian-Huang Huang et al. · Current Medicinal Chemistry · 0 citations

Open access Aug 2026

Single-cell transcriptomics identifies a putative perivascular macrophage–endothelial MIF–ACKR3 axis associated with endothelial activation in acute traumatic brain injury

Background Blood–brain barrier (BBB) disruption is a hallmark of acute traumatic brain injury (TBI), yet the immune–vascular mechanisms underlying endothelial dysfunction remain incompletely understood. Perivascular macrophages (PVMs) are strategically positioned to modulate cerebrovascular homeostasis, but their role...

Yan-Ya Lin, Cheng-Yu Lin, Jianhui Chen et al. · Frontiers in Cellular Neuros... · 0 citations

Open access Jul 2026

To construct a risk prediction model for poor discharge readiness in patients undergoing elective unilateral lower extremity joint replacement based on clinical and psychosocial factors

This study successfully developed a high-precision and interpretable machine learning prediction tool that can effectively identify high-risk patients with poor discharge readiness and highlights the critical impact of shortening hospital stay, preoperative psychological state, and socioeconomic status on rehabilitatio...

Dan-dan Lin, Yu-Cai Jiang, Lin-Lin Zheng et al. · Frontiers in Medicine · 0 citations