Degree of polymerization determines the absorption, metabolic fate, and urinary disposition of procyanidins in rats: A pharmacokinetic and metabolomic study.
The bioactivity of procyanidins (PCs) is closely associated with their degree of polymerization (DP), yet the pharmacokinetic mechanisms underlying these DP-dependent effects remain unclear. In this study, comparative pharmacokinetic and metabolomic analyses were performed in rats following gavage (250 mg/kg) of monome...