Author

Jianjun Ma

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Open access Sep 2026

HDAC1 maintains metabolic homeostasis in nucleus pulposus cells via post-translational modification interactions with YBX1

Intervertebral disc degeneration is characterized by the metabolic dysregulation of nucleus pulposus cells, which is regulated by complex post-translational modifications, manifesting as extracellular matrix remodeling and inflammatory microenvironment formation. We demonstrated the progressive downregulation of HDAC1...

Bo Zhou, Jie-Yun Xia, Zhao-Wei Zhang et al. · Experimental and Molecular M... · 0 citations

Review Aug 2026

Well Dispersion of Nanoparticles by Surface Modification: Strategies and Biomedical Applications.

Nanoparticles tend to aggregate in physiological environments, severely limiting their biomedical applications. This review systematically summarizes the research progress and biomedical applications of three core strategies via surface modification (covalent modification, coordinating modification, and hydrophobic int...

Yi-Meng Li, Xiaoyang Liu, Jian-Jun Ma et al. · Chemistry · 0 citations

Aug 2026

Bimetallic modified titanium carbide nanoparticles loaded with transcription factor E3 ameliorate intervertebral disc degeneration by eliminating reactive oxygen species and promoting autophagic flux.

In a needle puncture-induced IVDD rat model, intra-disc injection of Ti3C2@PtAu@TFE3 alleviated structural deterioration and prevented ECM destruction and the potential application of Ti3C2@PtAu@TFE3 against IVDD is demonstrated.

Jianle Wang, Tian-You Gao, Yingfeng Su et al. · International Journal of Bio... · 0 citations