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Author

Jian Liu

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Sep 2026

Complanatuside Ameliorates Renal Injury and Fibrosis in Chronic Kidney Disease by Inhibiting Tubular Cell Apoptosis via Activation of KLK1/BDKRB2.

BACKGROUND Chronic kidney disease (CKD) is characterized by renal fibrosis as a key pathological feature. Total flavonoids extracted from Astragalus complanatus can effectively alleviate renal fibrosis. However, the anti-fibrotic effect and the underlying specific mechanisms of its main active component, Complanatuside...

Jing Gao, Rui-Zhi Tan, Ke Deng et al. · 0 citations
Review Jul 2026

Chronic kidney disease‑associated encephalopathy: Clinical features, pathomechanisms and emerging therapeutic strategies (Review).

The present review systematically outlines the clinical manifestations, core pathogenic mechanisms and emerging therapeutic strategies for CKD‑associated encephalopathy, and the targeted interventions on the gut‑kidney‑brain axis.

Nanling Zeng, Ling Jiang, Yang Zhang et al. · 0 citations

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