Monoclonal antibodies (mAbs) have transformed the treatment of cancer and immune disorders, but their single-target nature limits efficacy against heterogeneous tumors and mutating pathogens. Recombinant polyclonal antibodies (RPABs)—defined as mixtures of typically 2–25 defined mAbs produced as a single drug substance...
Jiaqi Jin, Guo-Jiang Chen, Fenghao Peng et al.· Frontiers in Immunology· 0 citations
Single-cell RNA sequencing indicates that adulthood Rack1 deletion in type I interferon-I-responsive cells leads to aberrant lineage-geneset-scores of transcriptional HSCs and the emergence of stressed HSCs, and Mechanistically, RACK1 prevents HSC loss through maintaining the protein level of LDB1.
L. Deng, Jun-Jie Du, Zhe Xu et al.· Cell Death & Disease· 0 citations
This work evaluated ImmuneBuilder, IgFold, AlphaFold3, GRAMM, and dyMEAN on 50 non-redundant humanized antibody–antigen complexes using multiple retained predictions and paired statistical testing, finding all three antibody structure predictors were accurate.
Ze-Yuan Yu, Ji-Lei Wu, Zi-Yao Ning et al.· Bioinformatics Advances· 1 citation
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