Author

Jian Ruan

2 papers indexed here

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Open access Aug 2026

SYS6010, epidermal growth factor receptor-targeting antibody-drug conjugate for advanced non-small cell lung cancer: A phase 1 trial.

Overall, SYS6010 shows a manageable safety profile and encouraging antitumor activity in previously treated, advanced NSCLC.

Zi-Ming Li, Zhen Zhou, Zhi-Yong He et al. · Cancer Cell · 0 citations

Open access Sep 2026

PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype

PRKX drives immune exhaustion in the GC1 subtype by stabilizing PD-L1 through phosphorylation-dependent inhibition of ubiquitination, thereby promoting immune evasion and targeting PRKX represents a potential strategy to overcome resistance to anti-PD-1 therapy.

Qi-Yue Wang, Yin-Qi Chen, Dong-Dong Huang et al. · Journal for ImmunoTherapy of... · 0 citations