OBJECTIVE
To investigate the joint associations of depressive symptoms and mild cognitive impairment (MCI) with longitudinal cognitive and clinical progression in Parkinson's disease (PD).
METHODS
A cohort of 487 non-demented Parkinson's disease patients was categorized into normal cognition without depressive sympto...
Tianyu Hu, Chenqing Xu, Yilin Tang et al.· Parkinsonism & Related Disor...· 0 citations
This study suggests that polyG protein aggregates in NIID may shift the global RNA splicing profile toward an immature state, potentially through the sequestration of key splicing factors, such as SF3B4, thereby identifying new avenues for understanding the pathogenic mechanisms underlying NIID.
Jia-Xin Yang, You-Qi Zheng, Jian-Yi Hu et al.· Neuroscience Bulletin· 0 citations
It is reported, in a large cohort, that GBA-mutated PD patients exhibit lower serum cholesterol levels and cholesterol supplementation was found to enhance the autophagic flux and mitigate α-synuclein accumulation in vitro, whereas AAV-Srebp2 delivery increased α-synuclein clearance in GbaL444P/+ mice.
Mingjia Chen, Feng-Tao Liu, Yu-Jie Yang et al.· Cell Reports· 0 citations
Background Transmembrane protein 106B (TMEM106B) variations not only act as genetic modifiers of the risk of developing frontotemporal lobar degeneration but also correlate with the heterogeneity of clinicopathological phenotypes in other neurodegenerative diseases. However, the roles of TMEM106B in Parkinson’s disease...
Wanbing Zhao, Xiaoniu Liang, Bolin Hu et al.· Frontiers in Aging Neuroscie...· 0 citations
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