Berberine attenuates sepsis-associated myocardial injury and mitochondrial dysfunction through the AMPK/PGC-1α/NRF2 signaling pathway.
Berberine (Ber), a bioactive isoquinoline alkaloid derived from traditional Chinese herbs, has shown protective effects against sepsis-associated myocardial injury, although its underlying mechanisms remain unclear. This study investigated whether Ber attenuates LPS-induced myocardial injury by preserving mitochondrial...