Jian-Wu Tian

Self-assembly prodrugs for controlled singlet oxygen release and resistance modulation in deep-tumor photodynamic therapy.

Photodynamic therapy (PDT) offers spatiotemporally controlled tumor ablation via photosensitizer-mediated singlet oxygen (1O2) generation, yet its application to deep-seated solid tumors remains fundamentally constrained by limited light penetration and tumor hypoxia. Endoperoxides (EPOs), which reversibly capture and...