Sep 2026
Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.
It is suggested that MEM and low-dose HNK counteract inflammation-associated neural dysfunction in association with Trk-related signaling and require validation in both sexes before translational advantages can be inferred.
Xiao-Li Jia, Qi-Chao Gong, Bo-Cheng Xiong et al.
· Brain, behavior, and immunit... · 0 citations