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Author

Jianxiong Jiang

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Jul 2026

Abstract B074: Evaluation of a small molecule, AP-232, as a splicing factor inhibitor of U2 auxiliary factor 1 (U2AF1) in leukemia cells

Enhanced activity in SF3B1-mutant cells suggests that simultaneous targeting of splicing and autophagy dependencies may represent a therapeutic strategy for SF3B1–mutant hematological malignancies, potentially driven by increased reliance on autophagy as a survival mechanism in this genetic context.

Mona Kazemi Sabzvar, Amol D. Patil, Eun Bee Cho et al. · 0 citations

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