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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ji’an Yang

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2 papers indexed here

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Open access Sep 2026

Exploring novel isatin derivatives as SARS-CoV-2 3CLpro inhibitors

A series of novel isatin derivatives synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CLpro were strong inhibitors of SARS-CoV-2 3CLpro.

Jian Song, Cai Shi, Bo-Ning Yang et al. · 0 citations
Jul 2026

A Novel Dual-Targeting PROTAC Overcomes Endocrine Resistance by Engaging Orthosteric and Allosteric Sites of Estrogen Receptor α.

Estrogen receptor α (ERα) remains a pivotal therapeutic target for ER-positive (ER+) breast cancer, yet resistance to endocrine therapies driven by ligand-binding pocket (LBP) mutations demands novel strategies. To integrate the complementary strengths of binding modalities of the orthosteric LBP and the allosteric coa...

Chao Wang, Bin Xu, Lilan Xin et al. · 0 citations

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