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Author

Jian-You Liao

2 papers indexed here

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Open access Oct 2026

Representation learning of somatic missense mutation landscapes across cancer types

Somatic missense mutations are pervasive in cancer genomes, yet existing studies have largely compressed them into mutation burden, mutation signatures, or driver gene annotations. Such representations obscure mutation-specific context and higher-order dependencies, leaving the latent biological structure of somatic mu...

Ze-Lin Wang, Min-Fang Cai, Zhe-Wen Li et al. · 0 citations
Open access Oct 2026

Mitochondria-localized circRNA BRAKE restrains adipogenesis under nutrient overload by disrupting ATP synthase assembly in mice

Impaired adipogenesis contributes to obesity-associated metabolic disorders, in which mitochondrial dysfunction plays an important role. Emerging evidence suggests that mitochondria-localized circular RNAs (circRNAs) influence mitochondrial function; however, whether they regulate adipogenesis and systemic metaboli...

Yan-Rui Huang, Tian-Xing Zhu, Xiao-Si Hong et al. · 0 citations

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