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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jian-Yu Hu

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2 papers indexed here

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Open access Oct 2026

Accessibility and Alignment of Trans-Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein.

Mechanistic understanding of molecular interactions involved in the trans-cleavage of CRISPR ribonucleoprotein systems is critical to advance genome editing, cell imaging, DNA nanotechnology, and molecular diagnostics. However, the mechanisms underlying molecular interactions of the substrate with the ribonucleoprotein...

Jian-Yu Hu, Wei Feng, Hong-Quan Zhang et al. · 0 citations
Review Open access Sep 2026

Incorporating CRISPR Techniques with Electrochemical Sensors: From Signal-Off to Signal-On Assays.

Electrochemical biosensors integrating the programmable nucleic acid recognition of CRISPR systems with the low-cost and portable electrochemical transduction have emerged as powerful sensing platforms for molecular diagnostics. Early designs mainly relied on turn-off signal transduction, where target-activated CRISPR...

Chen-Yang Yang, Jian-Yu Hu, Hong-Quan Zhang et al. · 0 citations

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