POSTN⁺ CAF–SPP1⁺ macrophage crosstalk is associated with immune exclusion and poor prognosis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is a highly lethal malignancy in which the tumor microenvironment (TME) plays an important role in disease progression and therapeutic resistance. However, the spatial organization and molecular basis of stromal–immune interactions in LUAD remain incompletely understood. We integrated bulk RN...