Structural evolution of an ancient nucleotidyltransferase underlies divergence of AbiE antitoxins.
Type VII toxin-antitoxin (TA) systems neutralize toxins through antitoxin-mediated post-translational modification (PTM), with the oligoAMPylation-based HepT/MntA and phosphorylation-based AbiE systems representing the most prevalent families. Although the AbiE TA system from Mycobacterium tuberculosis is known to empl...