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Author

Jian Zhang

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Review Open access Sep 2026

The m6A methyltransferase METTL3 in intervertebral disc degeneration: from molecular mechanisms to therapeutic potential

Intervertebral disc degeneration (IDD) is the fundamental pathological process underlying low back pain, a major cause leading to disability worldwide. As the most prevalent methylation modification in eukaryotic RNA molecules, N6-methyladenosine (m 6 A) is involved in various diseases and cellular processes by reg...

Yi-Chun Zhou, X. Xiang, Geng Li et al. · 0 citations
Jul 2026

The USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

This study clarifies the molecular mechanism by which the USP5/MATN3 axis regulates cellular senescence and affects IVDD progression, opening up new potential targets for the intervention strategy of IVDD.

Chunyang Fan, Jie-yun Xia, Yao Zhang et al. · 0 citations

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