The NRF2 signaling pathway in hepatocellular carcinoma: dual roles, epigenetic reprogramming, and therapeutic opportunities in metabolic vulnerability
Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor with a poor prognosis; its onset and progression are closely associated with persistent oxidative stress and metabolic reprogramming. Nuclear factor E2-related factor 2 (NRF2), as a key transcription factor regulating redox homeostasis, exerts a c...