Author

Jian Zhou

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Open access Sep 2026

VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.

MAFLD is a global epidemic with a limited number of approved targeted therapies, underscoring the urgent need to define its underlying regulatory mechanisms. Here, we identify VGLL4 as a positive regulator of MAFLD progression. Hepatocyte-specific overexpression of Vgll4 induces hepatic steatosis, insulin resistance, a...

Yi-Xing Chen, Xiao-Dong Wang, Wen-Tao Yu et al. · EMBO Reports · 0 citations

Jul 2026

Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization.

A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.

Yun-Fan Sun, Y. Zhong, Shang Liu et al. · Science · 0 citations

Open access Jul 2026

cfDNA derived gene signatures as surrogate for microvascular invasion in HCC.

A circulating cfDNA-derived 5hmC signature that non-invasively predicts preoperative MVI status, with potential clinical utility in the management of resectable HCC patients is developed and validated.

Ruijie Gong, Linchen Wang, Dondon Xue et al. · JHEP Reports · 0 citations