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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jian Zhou

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Open access Oct 2026

Characterization of SPP1 + macrophages and their correlation with resistance to neoadjuvant chemotherapy in colorectal cancer liver metastasis

Neoadjuvant chemotherapy (NAC) for colorectal cancer liver metastasis (CRLM) remains a major clinical challenge, with outcomes varying widely among patients, yet the mechanisms that drive therapeutic resistance remain incompletely understood. In this study, we integrated single‑cell RNA‑sequencing and spatial transcrip...

Jing-Zhi Tang, Wei-Jie Hao, Xi-Gan He et al. · 0 citations
Jul 2026

FGFR2 Fusion-Driven CXCL3 Downregulation Attenuates Neutrophil Recruitment in Intrahepatic Cholangiocarcinoma.

Mechanistic insights are provided into the paradox between the oncogenic properties of FGFR2 fusion and favorable clinical outcomes in FGFR2 fusion-positive iCCA, and a potential strategy to optimize FGFR2-targeted therapies is suggested.

Tao Zhu, Jia-Cheng Lu, Yan-Zi Pei et al. · 0 citations

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