Jian Zhou

Addressing the Blind Spots of Deaminase Base Editors with CRISPR-Cas Glycosylase-Based Editors.

The emergence of CRISPR base editors signifies a pivotal shift in genome editing, moving beyond the "cut-and-paste" approach into an era of precise "chemical rewriting." While early editors including CBEs and ABEs enabled efficient base transitions by combining deaminases with Cas9 nickase, their core mechanism limited...