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Jianbin Chen

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Open access Aug 2026

Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant

Significance DNMT3A R882H (DNMT3AR882H) mutation is a hot-spot mutation in acute myeloid leukemia and developmental disorders. Previous studies have identified that DNMT3AR882H promotes the formation of high-order protein oligomers, giving rise to a dominant-negative effect on DNMT3A-mediated DNA methylation. This stud...

Jianbin Chen, Jiuwei Lu, Zhi-Xu Long et al. · 0 citations

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