Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and tissue repair. Traditionally considered passive regenerative cells, ISCs are now recognized as active environmental sensing hubs that integrate microbial, immune, metabolic, mechanical, and neural signals from the intestinal microenvi...
Jin-Xin Ma, Xiaoyun Jiang, Zhi-Cheng He et al.· Frontiers in Immunology· 0 citations
This framework suggests that therapeutic strategies should move beyond broad ADAM17 inhibition toward context-, cell-, or substrate-selective modulation that limits pathogenic signaling while preserving inflammation-resolving and tissue-repair functions.
Xiao-Dan Jiang, Jin-Xin Ma, Zhe-Jun Liu et al.· Frontiers in Pharmacology· 0 citations
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