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Author

Jiang Chen

2 papers indexed here

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Review Open access Aug 2026

Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation

Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and tissue repair. Traditionally considered passive regenerative cells, ISCs are now recognized as active environmental sensing hubs that integrate microbial, immune, metabolic, mechanical, and neural signals from the intestinal microenvi...

Jin-Xin Ma, Xiaoyun Jiang, Zhi-Cheng He et al. · 0 citations
Review Open access Sep 2026

ADAM17 as a proteolytic rheostat linking inflammation, tissue repair, and failure of inflammatory resolution in liver injury and fibrosis.

This framework suggests that therapeutic strategies should move beyond broad ADAM17 inhibition toward context-, cell-, or substrate-selective modulation that limits pathogenic signaling while preserving inflammation-resolving and tissue-repair functions.

Xiao-Dan Jiang, Jin-Xin Ma, Zhe-Jun Liu et al. · 0 citations

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