CDK1-mediated phosphorylation of APE1 drives synthetic lethality, p53-dependent metastasis, and immune sensitization in NSCLC
Cyclin-dependent kinase 1 (CDK1), a serine/threonine kinase essential for cell cycle progression, also plays critical roles in DNA damage response, gene expression regulation, and therapeutic resistance. In this study, we identify a previously unrecognized regulatory link between CDK1 and apurinic/apyrimidinic endonu...