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Review Sep 2026

Phytocannabinoid cannabidiol (CBD) in neurodegenerative diseases: From polypharmacology to drug development.

Cannabidiol (CBD) is a non-intoxicating phytocannabinoid that has attracted interest as a multi-target neurotherapeutic candidate for neurodegenerative diseases. CBD is a lipophilic terpenophenolic chemotype whose phenolic redox chemistry, membrane partitioning, cytochrome P450-mediated metabolism, and formulation-depe...

Bing-Xing Zhang, Jiang Nan, Yun-Fei Zhang et al. · 0 citations
Open access Sep 2026

Stereoselective Synthesis of β-4′-Hydroxymethyl-Deleted Nucleosides via CPA-Ph3PS Cooperative-Catalyzed Iodocyclization

β-4′-Hydroxymethyl-deleted nucleosides are a class of four-carbon-sugar isonucleosides that possess significant research value in medicinal chemistry and artificial genetic polymer science. Nevertheless, current synthetic methodologies are hampered by several drawbacks, including poor diastereoselectivity, considerable...

Qi Wang, Yu-Qian Liu, Yue-Yue Chen et al. · 0 citations

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