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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jiang Tan

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Open access Sep 2026

High-order enhancer hubs buffer allelic regulatory variation through kinetic compensation

Diploid genomes carry millions of heterozygous variants in cis-regulatory DNA, yet most genes produce similar RNA output from two parental alleles. How this balance is maintained is unclear. We developed Nanopore-HiChIP, a long-read method that maps high-order enhancer hubs on each haplotype. Over half of these enhance...

Jiang Tan, M. Sentmanat, Yu-Qing Wu et al. · 0 citations
Open access Aug 2026

NextLongIso: a comprehensive Nextflow pipeline for multi-dimensional long-read RNA-seq analysis

NextLongIso is presented, a scalable and reproducible Nextflow pipeline that enables coordinated analysis of multiple layers of transcript regulation and facilitates the transition from transcript identification to functional interpretation of transcriptomic variation.

Jiang Tan, Yu-Qing Wu, Yi-Dan Sun · 0 citations

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