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Author

Jiangyue Liu

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2 papers indexed here

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Review Open access Aug 2026

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

This review critically evaluates recent mechanistic advances in CDK/cyclin biology and their pathological dysregulation across malignancies and highlights emerging approaches including proteolysis‐targeting chimeras, HSP90‐mediated targeting chimeras, hydrophobic tagging, molecular glues, and autophagy‐tethering compou...

Su-Ya Zheng, Zhi-Peng Shen, Yuan-Fang Wu et al. · 0 citations
Open access Aug 2026

Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers

MDM2 is an oncogenic E3 ubiquitin ligase best known for targeting the tumor suppressor p53 and is frequently amplified in human cancers, including dedifferentiated liposarcoma (DDLPS). We show that supraphysiological MDM2 expression can be exploited to reprogram its ligase activity toward selective degradation of o...

Ye Chen, Long Xie, Xian Guan et al. · 1 citation

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